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Reductil commonly known as sibutramine, is considered highly effective in treating obesity. This drug works in two productive ways; first it builds a feeling of fullness so that the patient feels satisfied in a flash even after an intake of little portions of meal and it also reduces the frequency of cravings for unhealthy food. Secondly, it aids in restraining the metabolism of the body from slowing down. The active ingredient found in reductil is sibutramine hydrochloride monohydrate which is considered efficacious for reducing weight.


The working of reductil is different from traditional weight loss pills as it operates by obstructing the reuptake of a neurotransmitter known as serotonin. It results in the presence of a greater quantity of serotonin in the brain that is linked with smaller appetite. Reductil is found in five, ten and fifteen milligrams doses and is only taken orally. It is mostly recommended to people who have tried different weight loss methods but nothing worked and having body mass index BMI of over 30 kg/ m2. Not every person using reductil report side effects but some of its common side effects are: nausea, hot flushes, headache, insomnia, constipation, sweaty hands and dry mouth etc. This drug is not considered an addictive medicine as it is licensed to use for long durations for treating obesity. Sibutramine, is primarily used to assist overweight people in losing weight by adjusting neurotransmitters inside the brain.

Neurotransmitters are defined as chemicals generated and released through nerves for communicating with other nerves. The neurotransmitters released may stick to other nerves or may be absorbed again by those nerves that usually release them. This processed is called reuptake. Thus, sibutramine used to obstruct reuptake of serotonin, norepinephrine and neurotransmitters dopamine. This obstruction of the reuptake of neurotransmitters alters neurotransmitters balance inside the nerve cells which affects the interaction and function of the nerve.

Sibutramine belongs to the "appetite suppressants" class of medications that help in reducing the cravings and hunger through alteration in the appetite control centers present in the brain.

Sibutramine was considered an effective drug for weight loss when taken with a healthy low calorie diet and exercise. It was also recommended for treating obesity related to high cholesterol, diabetes and high blood pressure. Bodybuilders who used to take sibutramine were likely to achieve a reduction of 5 to 10% from their weight.


Sibutramine has a half-life of 14-16 hours, which is why dosing once a day at a breakfast is quite sufficient. The usual starting dose of 15 mg is enough, it should lead to the desired effect in most cases. Those, who feel the dose as insufficient, increase the dose to a maximum - the maximum is 20 mg, and it is an entirely uppermost limit. For bodybuilders the same dosages applies. Though, there could be some variation due to size (weight).

In each case, the user must be careful about blood pressure, especially when combine Sibutramine with anabolic/androgenic steroids.Regardless of the administered Sibutramine dose, the duration of obesity drug therapy should not exceed 2 years.

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