IGF-1 DES (1-3), short for Insulin-Like Growth Factor-1 DES 1 - 3, is among the most popular peptides available, as is the conventional IGF-1 LR3. It generates new muscle cells and thereby affects muscle growth enormously. Compared to the conventional IGF-1 LR3, IGF-1 DES (1-3) is said to be stronger, faster and more fat-burning. Everything you should know about this topic can be found here:
IGF-1 DES (1-3) is a shortened variant of the conventional IGF-1 with a so-called tri-peptide structure. It has been purposefully isolated so that it can be more effective in certain tissue types. Due to the altered structure, IGF-1 DES (1-3) is 10 times more potent than IGF-1 in the hypertrophy and proliferation of so-called satellite cells in muscle tissue and other tissues. In addition, it should have a much more metabolic, so fat-burning effect than conventional IGF-1.
As such, IGF-1 normally occurs when testosterone, HGH (growth hormone) and insulin meet in the liver. IGF1 does not just provide muscle growth, but the formation of completely new muscle cells. This results in the new formation of completely new muscle mass.
The effect of IGF-1 DES (1-3) is four times faster than that of conventional IGF-1, although the fat-burning effects last three to five times longer than those of conventional IGF-1. This is related to the fact that IGF-1 DES (1-3) is subsequently found in higher concentrations in the target tissue than IGF-1. Originally, IGF-1 DES (1-3) was made for inflammation and intestinal disorders, as it, among other things, specifically strengthens intestinal tissue. In addition, IGF-1 DES (1-3), like other forms of IGF-1, is used in the treatment of catabolic effects in general or certain diseases.
It has also been shown that IGF-1 DES (1-3) has one to three times greater effects on tissue growth, predominantly muscle tissue, compared to IGF-1. Wound healing is also greatly accelerated.
Completely different from conventional IGF-1 or Long R3, IGF-1 DES (1-3) is injected about 15 minutes before training due to its high potency and altered structure. Here the variant is chosen subcutaneously or divided intra-muscularly into the muscle to be trained. The dosages are 25-100 mcg. The lowest dose is very low, but this is related to the stronger effect of IGF-1 DES (1-3). An application period of more than 6 weeks is generally not recommended.
In the forums you will find many different schemes such as injections of 25-40 mcg before, as well as after training, or 100 mcg subcutaneously every two days. In the course of the application, however, the above-mentioned dosage has proven to be the most effective scheme.
As with conventional IGF-1 or IGF-1 LR3, IGF-1 DES (1-3) again states that nothing precise can be said about the side effects and that the enumerated things are derived from empirical values. However, what is very well known is that IGF generally causes general growth of tissue, which also affects tumours, etc. Other side effects that may occur are: