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Post Cycle Therapy (PCT)


Many substances such as clomiphene and also tamoxifen are mainly used to inhibit or even block estrogen production in post-cycle therapy, the so-called PCT, and at the same time to restart the testosterone production. In the case of Arimidex (anastrozole), however, it is also a very potent remedy in post-cycle therapy. However, it is often used during highly dosed steroid cures to inhibit both estrogen production and block aromatase, i.e. conversion from free testosterone to estrogen. This mainly prevents estrogen-induced side effects. All you should know about this topic is here:


Arimidex (anastrozole) is a substance from the third generation of selective aromatase inhibitors and is primarily used for medical purposes in patients with breast cancer. The effect of Arimidex (anastrozole) is due to the partial blocking of the so-called aromatase enzyme, which in the normal case converts testosterone into estrogen, which promotes, for example, water retention, acne, gynecomastia, mood fluctuations and also tumor growth. The radical reduction of the estrogen level helps to counteract these side effects and prevent them from occurring. Athletes use Arimidex (anastrozole) primarily to prevent the aromatase from anabolic steroids. In this area, Arimidex (anastrozole) is extremely effective.


It has been shown that the dosage of 1mg Arimidex (anastrozole) can already reduce estrogen level by 70%. At a daily dosage of 1mg over 14 days, even a reduction of 80% can be achieved. Even after the end of the intake, a greatly reduced estrogen level can still be detected after 6 days. In combination with medium to strong aromatizing steroids such as, for example, testosterone enanthate, side effects such as, for example, increased fat and water retention can be prevented or avoided. Although the use here is effective and useful, it should be carefully considered, since a complete elimination of the estrogen production also has disadvantages due to the fact that estrogen also has anabolic components. This may also lead to reduced muscle growth. In addition, the estrogen also promotes growth hormone production and is also involved in the formation of IGF-1. In addition, estrogen has beneficial effects on cholesterol and calcium levels. For these reasons, especially the decreased water storage, users of Arimidex (anastrozole) often report joint pain.

Because of the reasons mentioned, it should also be considered in the case of ancillary steroids that the estrogen production is not completely blocked, as a slight inhibition of the aromatase enzyme is usually sufficient to avoid estrogen-induced side effects.

In the case of a diet or a competition preparation, however, this is different. Since estrogens primarily promote the storage of fat in the problem zones, it is advantageous here to achieve a complete inhibition of the aromatase enzyme or of the estrogen production. As a rule, Arimidex (anastrozole) is combined with tamoxifen in order to prevent the formation and binding of residual estrogen to the respective receptors. After the completion of a competition phase, the dose of Arimidex (anastrozole) is then reduced over a longer period of time, as a rebound often occurs in the case of rapid discontinuation.

In addition, the ratio of estrogens to androgens in the body shifts, which is reflected in an increased harshness and definition.


Athletes who want complete suppression of the estrogen generally use 1mg per day. As already mentioned, this dosage makes sense only in a diet or for a competition preparation, since anabolic mechanisms are affected here. For masseurs, in which the aromatase of steroids is to be prevented, without great affecting anabolic components, already 0,5-1g are enough every 2 days. Depending on the purpose, the half-life of 40-50 hours can be used.

Arimidex (anastrozole) can be taken between or in combination with the meals, as they have little effect on the active substance.


With regard to the side effects there are above all known hot flashes, fatigue, headache, depression, sleep disturbances, deterioration of the cholesterol values, joint pain due to the disturbed calcium metabolism and an increase of the liver values.


When Arimidex (anastrozole) is discontinued, it is important to reduce the dosage stepwise, for example from 1g to 0.5g to 0.25g, and to extend the intervals (1-3 days). If Arimidex (anastrozole) is rapidly discontinued, a rapid rise in estrogen level is caused, resulting in a strong rebound.

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