Known for its drastic effects on fat burning, muscle tone and the increase in muscle mass in general, growth hormones are now very popular in performance sports, bodybuilding, fitness and for anti-aging purposes despite the intensive costs. Everything you should know about growth hormones you can find here:
The human growth hormone, which is also known under the names HGH, STH and somatropin, was first produced in the early 1980s for the treatment of small children. Since there was initially no possibility of artificially producing human growth hormone, HGH was first obtained from the pituitary gland of corpses. Unfortunately, in the application of this growth hormone obtained from corpses, in rare cases the transmission of the Jakob Kreutzfeld disease, an incurable, fatal brain disease, has occurred. This led to the development of artificially produced somatropin, which was produced with the aid of genetically modified E. coli bacteria.
Structurally, human growth hormone is a peptide hormone consisting of a sequence of 191 amino acids. In the body, HGH is produced and poured out by the pituitary gland. The release of growth hormone is at its greatest during a period of young years during the growth phase and decreases further in the adult age, but the pituitary gland releases growth hormones all its life.
HGH has a whole range of properties that make it very interesting for bodybuilders and other sportsmen. First of all, somatropin promotes the growth of body tissue throughout the body, which is mainly the muscle tissue. This growth promotion of HGH is primarily based on an increase in the number of cells in the corresponding tissue, which is based on an increased cell division rate, and to a lesser extent also on a size growth of the cells. In addition, the human growth hormone promotes the uptake of amino acids into the cells and accelerates the rate at which these amino acids are synthesized in the cells into proteins, which is equivalent to an increased protein synthesis rate, thus causing much faster muscle growth. These processes are actually triggered by IGF-1, which is produced in response to increased growth hormone levels in the liver and other body tissue types. This growth-promoting effect of somatropin also affects articular cartilage, connective tissue and other stabilizing structures in the body, which reduces the susceptibility to injury and promotes healing of existing damage.
Another feature of HGH, which is appreciated by bodybuilders, is the promotion of the reduction of body fat. Somatropin is able to reduce the rate at which body cells use carbohydrates for the purpose of energy supply, while at the same time increasing the rate at which fat is used as a source of energy. In addition, growth hormone promotes the scission of body fat in adipose tissue. Already 0.028 IU of somatropin per kilogram of body weight per day are sufficient to show a clear effect with regard to fat burning. This would be a daily dose of 2.8 IU HGH per day for a 100 kilo bodybuilder.
As with all other medicines, side effects can also occur with somatropin. These are usually based on the use of higher dosages and may include increased growth of the bones (mainly in the area of the feet, forehead, hands, jaw and elbows) as well as growth of the inner organs such as heart and kidneys. Furthermore, the use of HGH due to its ability to promote insulin resistance is associated with the development of diabetes.
Since growth hormones are a very expensive active substance, many bodybuilders use HGH either in low doses or for a too short period of time to feel significant effects. It has been found that continuous, uniform gains through growth hormone become apparent only after an application period of about two months. The dosages observed here are in the range of 4 to 6 IU of somatropin per day, while dosages in the range of 8 to 32 IU of HGH and more are the rule in competition bodybuilders. The period of use of growth hormone observed in practice begins at 3 months and is usually in the range of 6 months, although there are also bodybuilders who use somatropin throughout the year. HGH can be injected both subcutaneously and intramuscularly, with daily or even twice daily injections due to the very short half-life of somatropin in the body. Sportsmen usually use growth hormone in conjunction with androgen-acting steroids such as testosterone to promote muscle growth through two different mechanisms. In addition to this, thyroid hormones (Liothyronine / T3) and insulin are often used in conjunction with somatropin, since HGH reduces the body's own release of these two hormones.