Similarly popular as ephedrine, clenbuterol is extremely popular in diets, as its fat-burning properties are among the strongest on the market. For this reason it is used not only in bodybuilders, but also more and more in normal people in weight reduction. All further information on clenbuterol you will find here:
Clenbuterol, which is officially known under the name Spiropent in Germany, is a so-called beta-2 sympathetic methotome, similar to ephedrine, which is originally used for the treatment of asthma because it stimulates the smooth muscle tissue of the respiratory tracts and thereby leads to an expansion of the respiratory tracts. Although clenbuterol is not an anabolic steroid, clenbuterol is very popular in bodybuilding area. This has two reasons related to the effect of clenbuterol. On the one hand clenbuterol is anabolic and anticatabolic and on the other hand clenbuterol promotes fat loss during a diet.
The anabolic effect predicted from clenbuterol is due to some studies carried out with animals which showed a clear anabolic effect of clenbuterol. Unfortunately, these studies are not available to humans, which is due to the fact that the doses of clenbuterol used in these studies were about a thousandfold of the therapeutic dosage used in humans.
Furthermore, the anabolic effect of clenbuterol in animals appears to be based on mechanisms which are not present in humans, or only very weakly. Thus, the use of clenbuterol for building muscle mass can actually be considered uninteresting. The same applies to the alleged anticatabolic effect of Spiropent since there are no studies showing such an effect of clenbuterol. The only effect of clenbuterol, which could be beneficial for muscle building, is the often observed increase in strength, which is probably due to the fact that muscles can contract more strongly under the action of clenbuterol. Interestingly, many users report that this effect is only noticeable in the first administration cycle of clenbuterol and is only weak or not present at all in later administration phases.
The far more interesting application area of Spiropent is the promotion of fat burning during the diet. Clenbuterol is also a beta-receptor agonist, as is ephedrine. The difference, however, is that clenbuterol is a selective beta-2 receptor agonist, which means that clenbuterol acts almost exclusively on the beta-2 receptors whereas ephedrine stimulates all three beta receptor types of the body. Theoretically, clenbuterol is less likely to affect the cardiovascular system than ephedrine due to the lack of excitation of the beta-1 receptors, whereas the users of clenbuterol report on side effects connected with the cardiovascular system, such as nocturnal accelerated pulse and slight cardiac arrhythmias.
The fat-burning effect of beta-receptor agonists such as clenbuterol or ephedrine is mainly due to a slight increase in the body temperature, which is caused by the fact that the heat production in the mitochondria of the cells is increased, ultimately resulting in an increase in the basic turnover. In addition to this, clenbuterol causes a slight suppression of the feeling of hunger, which is however less than the comparable effect of ephedrine.
In practice, it is observed that Spiropent's fat burning effect is most severe during the first two weeks of use and then rapidly decreases. This effect is based on the fact that clenbuterol down-regulates the sensitivity of the beta-2 receptors quite quickly, which of course also reduces the effect.
In order to be able to effectively use clenbuterol over a longer period of time, bodybuilders have developed different strategies over the years. The oldest of these strategies, which is unfortunately still quite common today, is to use a 2-day-on, 2-day-off-schedule after the first two weeks of application to allow beta-2 receptors to be exposed for two days each to regenerate. However, it is only necessary to look at the long half-life of clenbuterol, which is in the range of 35 hours, in order to see that such an approach is doomed to failure. More effective are, on the other hand, the intake pattern, in which clenbuterol is taken for one to two weeks, followed by one to two weeks without taking. During these weeks, many bodybuilders use ephedrine instead of clenbuterol, but this is not a particularly useful strategy because ephedrine stimulates the beta-2 receptors in addition to the beta-1 and beta-3 receptors, thus preventing a recovery of the receptors. In practice, the use of fat-burning active substances which are not associated with the beta-receptors, such as, e.g. Yohimbine, has been proved as more meaningful.
Another in the strategy is the concomitant intake of ketotifen, which increases the sensitivity of the beta-2 receptors. The same applies to the thyroid hormone, Liothyronine (T3), which itself has a distinct fat-burning effect.
The most common dosages used in Spiropent are in the range of 20 to 160 mcg, usually with a lower dosage of clenbuterol, which is then slowly increased during the course of the application. Due to the long half-life of clenbuterol, most users use clenbuterol in two doses, with lower doses of clenbuterol often taken only in the morning.
Side effects of clenbuterol include, but are not limited to, insomnia, hand tingling, cardiovascular problems, and increased spasm. Most of these side effects decrease with increasing administration time. The increased tendency to spasms can be counteracted by adequate fluid intake and the intake of a magnesium preparation. However, the fact that clenbuterol can lead to necrosis (cell death) in the area of the heart muscle and that clenbuterol as a beta-2 agonist reduces insulin sensitivity is far more serious than these clearly perceptible side effects.